COTRIM 480 W
Water dispersible powder
Trimethoprim 80 mg/g
Sulphadiazine (as sodium) 400mg/g
COTRIM 480W is a combination trimethoprim and sulfadiazine in the form of the water soluble sodium salt, at a 1:5 ratio. Trimethoprim is a pyrimidine derivate with a bacteriostatic activity against Gram-positive and Gram-negative germs. Sulfadiazine is a shortly acting bacteriostatic sulfonamide with an antibacterial spectrum that complies with that of trimethoprim. As both ingredients influence two successive reactions of the same bacterial biochemical process, one can expect that resistance development against the combination arises much slower than against the separate components. Trimethoprim and sulfadiazine show the same pharmacokinetic pattern. Trimethoprim has a larger distribution volume and concentrates itself better in the tissues than sulfadiazine.
For the prevention and treatment of general bacterial infections of the respiratory and digestive systems and the urogenital tract in broilers and poultry breeders caused by the following germs: Streptococci, Staphylococci, E. coli, Salmonella spp., Clostridia.
COTRIM 480W is useful for the control of the following poultry diseases: Coli-septicaemia, infectious coryza, infectious sinusitis, pasteurellosis, salmonellosis, staphylococcal arthritis and secondary bacterial infections associated with viral respiratory disease and mycoplasmosis.
COTRIM 480W is contra-indicated in animals with a known hypersensitivity against sulfonamides.
DOSAGE AND MODE OF ADMINISTRATION
Add 200-400 g COTRIM 480 W per 1000 litres of drinking water. Treat for 4-5 consecutive days (only medicated should be available). The higher dosage rate should be used for the treatment of coli-septicaemia.
In high ambient temperatures, when water consumption is increased, the level of inclusion of Cotrim 480 W should be reduced accordingly.
Medicated water should be used within 24 hours.
A long term treatment can end in folic acid deficiency with suppression of the bone marrow activity and the haematopoiesis.
SPECIAL PRECAUTIONS AND WARNINGS
The powder should be mixed thoroughly in the drinking water. A fresh solution should be prepared for each oral administration. During mixing of the powder, direct skin contact and dust inhalation should be avoided. Store out of reach of children.
100 g, 500 kg, 5 kg.
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